Anti-Sigma1-receptor抗体(ab71292)

概述

  • 产品名称Anti-Sigma1-receptor抗体
    参阅全部 Sigma1-receptor 一抗
  • 描述
    兔多克隆抗体to Sigma1-receptor
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Sigma1-receptor aa 118-147 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: Q99720

  • 阳性对照
    • Sigma1-receptor-transfected 293 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab71292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 28 kDa (predicted molecular weight: 25 kDa).

靶标

  • 功能Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
  • 组织特异性Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells.
  • 疾病相关Amyotrophic lateral sclerosis 16, juvenile
  • 序列相似性Belongs to the ERG2 family.
  • 细胞定位Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aging associated gene 8 protein antibody
    • Aging-associated gene 8 protein antibody
    • AL024364 antibody
    • hSigmaR1 antibody
    • mSigmaR1 antibody
    • opioid receptor, sigma 1 antibody
    • opioid receptor, sigma 1 isoform 1 antibody
    • RP23 167I12.6 antibody
    • SGMR1_HUMAN antibody
    • SIG 1R antibody
    • SIG-1R antibody
    • Sigma 1-type opioid receptor antibody
    • Sigma non-opioid intracellular receptor 1 antibody
    • sigma1 receptor antibody
    • Sigma1-receptor antibody
    • Sigma1R antibody
    • Sigmar1 antibody
    • SR BP antibody
    • SR-BP antibody
    • SR31747 binding protein antibody
    • SR31747-binding protein antibody
    • SRBP antibody
    see all

Anti-Sigma1-receptor antibody 图像

  • All lanes : Anti-Sigma1-receptor antibody (ab71292) at 1/50 dilution

    Lane 1 : Non-transfected 293 cell lysates
    Lane 2 : 293 cell lysates transiently transfected with the OPRS1 gene

    Lysates/proteins at 12.5 µg per lane.


    Predicted band size : 25 kDa
    Observed band size : 28 kDa (why is the actual band size different from the predicted?)

Anti-Sigma1-receptor antibody (ab71292)参考文献

ab71292 has not yet been referenced specifically in any publications.

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