概述

  • 产品名称
    Anti-SIGLEC9抗体[MM0552-6K12]
    参阅全部 SIGLEC9 一抗
  • 描述
    小鼠单克隆抗体[MM0552-6K12] to SIGLEC9
  • 经测试应用
    适用于: ICC/IF, WB, Neutralisingmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant fragment of Human SIGLEC9 extracellular domain.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • 克隆
    单克隆
  • 克隆编号
    MM0552-6K12
  • 同种型
    IgG2
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab89484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 25673840
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Neutralising Use at an assay dependent concentration.

靶标

  • 功能
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 组织特异性
    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
  • 序列相似性
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD329 antibody
    • CDw329 antibody
    • FOAP 9 antibody
    • OB binding protein like antibody
    • OBBP LIKE antibody
    • Protein FOAP 9 antibody
    • Protein FOAP-9 antibody
    • sialic acid binding Ig like lectin 9 antibody
    • Sialic acid-binding Ig-like lectin 9 antibody
    • Sialic acid-binding immunoglobulin like lectin 9 antibody
    • SIGL9_HUMAN antibody
    • Siglec 9 antibody
    • Siglec-9 antibody
    • SIGLEC9 antibody
    see all

Anti-SIGLEC9 antibody [MM0552-6K12] (ab89484)参考文献

This product has been referenced in:
  • Matsubara K  et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci 35:2452-64 (2015). ICC/IF ; Rat . Read more (PubMed: 25673840) »
  • Brazil JC  et al. a3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration. J Immunol 191:4804-17 (2013). Read more (PubMed: 24068663) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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