概述

  • 产品名称Anti-SIGLEC9抗体[MM0552-6K12]
    参阅全部 SIGLEC9 一抗
  • 描述
    小鼠单克隆抗体[MM0552-6K12] to SIGLEC9
  • 经测试应用适用于: WB, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment of Human SIGLEC9 extracellular domain.

性能

应用

Our Abpromise guarantee covers the use of ab89484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Neutralising Use at an assay dependent dilution.

靶标

  • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 组织特异性Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
  • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD329 antibody
    • CDw329 antibody
    • FOAP 9 antibody
    • OB binding protein like antibody
    • OBBP LIKE antibody
    • Protein FOAP 9 antibody
    • Protein FOAP-9 antibody
    • sialic acid binding Ig like lectin 9 antibody
    • Sialic acid-binding Ig-like lectin 9 antibody
    • Sialic acid-binding immunoglobulin like lectin 9 antibody
    • SIGL9_HUMAN antibody
    • Siglec 9 antibody
    • Siglec-9 antibody
    • SIGLEC9 antibody
    see all

Anti-SIGLEC9 antibody [MM0552-6K12] (ab89484)参考文献

This product has been referenced in:
  • Brazil JC  et al. a3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration. J Immunol 191:4804-17 (2013). Read more (PubMed: 24068663) »

See 1 Publication for this product

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