Anti-SIGLEC8抗体[7C9] (ab103398)

概述

  • 产品名称Anti-SIGLEC8抗体[7C9]
    参阅全部 SIGLEC8 一抗
  • 描述
    小鼠单克隆抗体[7C9] to SIGLEC8
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Siglec-8-Fc protein, containing entire extracellular region of Human Siglec-8 fused with the Fc region of human IgG1.

  • 阳性对照
    • Siglec-8 CHO cells vs non-transfected CHO cells.

性能

应用

Our Abpromise guarantee covers the use of ab103398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.

靶标

  • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 组织特异性Expressed specifically on eosinophils.
  • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD329 antigen antibody
    • CDw329 antibody
    • SAF 2 antibody
    • SAF-2 antibody
    • SAF2 antibody
    • Sialic acid binding Ig like lectin 8 antibody
    • Sialic acid-binding Ig-like lectin 8 antibody
    • Sialoadhesin family member 2 antibody
    • SIGL8_HUMAN antibody
    • Siglec 8 antibody
    • Siglec-8 antibody
    • SIGLEC8 antibody
    • SIGLEC8L antibody
    see all

Anti-SIGLEC8 antibody [7C9] (ab103398)参考文献

ab103398 has not yet been referenced specifically in any publications.

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