概述

  • 产品名称
    Anti-SIGLEC6抗体
    参阅全部 SIGLEC6 一抗
  • 描述
    山羊多克隆抗体to SIGLEC6
  • 特异性
    ab104930 is expected to recognize all reported isoforms (NP_001236.4; NP_942142.3; NP_942143.3).
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 126-136 (

    KWMKYGYTSSK

    ) of Human SIGLEC6 (NP_001236.4; NP_942142.3; NP_942143.3)

  • 阳性对照
    • Human placenta lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 50 kDa. Experiments gave bands at approx 60kDa and 35kDa in Human Placenta lysates. These bands correspond to earlier findings with different antibodies from other commercial sources.

靶标

  • 功能
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 组织特异性
    Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
  • 序列相似性
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD327 antibody
    • CD33 antigen-like 1 antibody
    • CD33L antibody
    • CD33L1 antibody
    • CD33L2 antibody
    • CDw327 antibody
    • OB-BP1 antibody
    • OBBP1 antibody
    • Obesity-binding protein 1 antibody
    • Sialic acid-binding Ig-like lectin 6 antibody
    • SIGL6_HUMAN antibody
    • Siglec-6 antibody
    • SIGLEC6 antibody
    see all

图片

  • Anti-SIGLEC6 antibody (ab104930) at 0.5 µg/ml + Human placenta lysate in RIPA buffer at 35 µg

    Predicted band size : 50 kDa

实验方案

文献

ab104930 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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