概述

  • 产品名称Anti-SIGLEC5抗体
    参阅全部 SIGLEC5 一抗
  • 描述
    兔多克隆抗体to SIGLEC5
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human SIGLEC5 conjugated to KLH

  • 阳性对照
    • Mouse liver tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab38582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).

靶标

  • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 组织特异性Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
  • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD170 antibody
    • CD170 antigen antibody
    • CD33 antigen-like 2 antibody
    • CD33L2 antibody
    • mSiglec-F antibody
    • OB-binding protein 2 antibody
    • OB-BP2 antibody
    • OBBP2 antibody
    • Obesity-binding protein 2 antibody
    • Sialic acid binding Ig-like lectin 5 antibody
    • Sialic acid binding immunoglobulin-like lectin 5 antibody
    • Sialic acid-binding Ig-like lectin 5 antibody
    • Sialic acid-binding Ig-like lectin F antibody
    • SIGL5_HUMAN antibody
    • Siglec-5 antibody
    • Siglec-F variant antibody
    • Siglec5 antibody
    • Siglecf antibody
    see all

Anti-SIGLEC5 antibody 图像

  • Anti-SIGLEC5 antibody (ab38582) at 1/100 dilution + Mouse liver tissue lysate

    Predicted band size : 61 kDa
    Observed band size : 61 kDa
    Additional bands at : 41 kDa,75 kDa. We are unsure as to the identity of these extra bands.

Anti-SIGLEC5 antibody (ab38582)参考文献

ab38582 has not yet been referenced specifically in any publications.

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