概述

  • 产品名称Anti-SIGLEC11抗体
    参阅全部 SIGLEC11 一抗
  • 描述
    兔多克隆抗体to SIGLEC11
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) from the C-terminus of human SIGLEC11, conjugated to KLH.

  • 阳性对照
    • Human hepatocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab59944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 组织特异性Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻译后修饰Phosphorylated on tyrosine residues.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • sialic acid binding Ig like lectin 11 antibody
    • sialic acid binding lectin 11 antibody
    • Sialic acid-binding Ig-like lectin 11 antibody
    • Sialic acid-binding lectin 11 antibody
    • SIG11_HUMAN antibody
    • Siglec 11 antibody
    • Siglec-11 antibody
    • SIGLEC11 antibody
    see all

Anti-SIGLEC11 antibody 图像

  • ab59944 at 1/50 - 1/100 dilution, staining SIGLEC11 in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-SIGLEC11 antibody (ab59944)参考文献

ab59944 has not yet been referenced specifically in any publications.

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