概述

  • 产品名称Anti-SIGLEC11抗体
    参阅全部 SIGLEC11 一抗
  • 描述
    兔多克隆抗体to SIGLEC11
  • 特异性Specific to Human SIGLEC11, does not cross react with SIGLEC10.
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).

  • 阳性对照
    • HepG2 cell lysate Human liver tissue

性能

应用

Our Abpromise guarantee covers the use of ab106390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 组织特异性Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻译后修饰Phosphorylated on tyrosine residues.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • sialic acid binding Ig like lectin 11 antibody
    • sialic acid binding lectin 11 antibody
    • Sialic acid-binding Ig-like lectin 11 antibody
    • Sialic acid-binding lectin 11 antibody
    • SIG11_HUMAN antibody
    • Siglec 11 antibody
    • Siglec-11 antibody
    • SIGLEC11 antibody
    see all

Anti-SIGLEC11 antibody 图像

  • Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.

  • Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg

    Predicted band size : 76 kDa
  • ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-SIGLEC11 antibody (ab106390)参考文献

ab106390 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106390.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"