概述

  • 产品名称
    Anti-SIGLEC10抗体
    参阅全部 SIGLEC10 一抗
  • 描述
    兔多克隆抗体to SIGLEC10
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C-terminal region of Human SIGLEC10.

  • 阳性对照
    • HeLa Cell Lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab112564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 77 kDa.

靶标

  • 功能
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 组织特异性
    Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
  • 序列相似性
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 结构域
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻译后修饰
    Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • mSiglec G antibody
    • PRO940 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody
    • sialic acid binding Ig like lectin G antibody
    • Sialic acid binding Immunoglobulin like lectin 10 antibody
    • Sialic acid-binding Ig-like lectin 10 antibody
    • SIG10_HUMAN antibody
    • SIGLEC 10 antibody
    • Siglec G antibody
    • siglec like gene 2 antibody
    • Siglec like protein 2 antibody
    • Siglec like protein 2 antibody
    • Siglec-10 antibody
    • Siglec-like protein 2 antibody
    • SIGLEC10 antibody
    • Siglecg antibody
    • SLG2 antibody
    see all

图片

  • Anti-SIGLEC10 antibody (ab112564) at 1/100 dilution + HeLa Cell Lysate at 35 µg

    Predicted band size : 77 kDa

实验方案

文献

ab112564 has not yet been referenced specifically in any publications.

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