Anti-Siglec 7抗体[MM0551-8D8] (ab89483)

概述

  • 产品名称Anti-Siglec 7抗体[MM0551-8D8]
    参阅全部 Siglec 7 一抗
  • 描述
    小鼠单克隆抗体[MM0551-8D8] to Siglec 7
  • 特异性ab89483 cross reacts with Siglec 14.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment of Human Siglec 7 extracellular domain.

性能

应用

Our Abpromise guarantee covers the use of ab89483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: 1/20 - 1/200.
    WB: 1/500 - 1/1000. Predicted molecular weight: 51 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
    • 组织特异性Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
    • 序列相似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • 翻译后修饰Tyrosine phosphorylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Adhesion inhibitory receptor molecule 1 antibody
      • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
      • AIRM 1 antibody
      • AIRM-1 antibody
      • AIRM1 antibody
      • CD328 antibody
      • CD328 antigen antibody
      • CDw328 antibody
      • D siglec antibody
      • D-siglec antibody
      • HLDA 8 antibody
      • p75 antibody
      • p75/AIRM1 antibody
      • QA79 antibody
      • QA79 membrane protein antibody
      • Sialic acid binding Ig like lectin 7 antibody
      • Sialic acid binding immunoglobulin like lectin 7 antibody
      • Sialic acid-binding Ig-like lectin 7 antibody
      • SIGL7_HUMAN antibody
      • Siglec-7 antibody
      • SIGLEC19P antibody
      • SIGLEC7 antibody
      • SIGLECP2 antibody
      see all

    Anti-Siglec 7 antibody [MM0551-8D8] (ab89483)参考文献

    ab89483 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab89483.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"