概述

  • 产品名称Anti-SIGIRR抗体
    参阅全部 SIGIRR 一抗
  • 描述
    兔多克隆抗体to SIGIRR
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A synthetic peptide corresponding to 15 amino acids at the carboxy terminus of mouse SIGIRR.

  • 阳性对照
    • A549 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified IgG was prepared from whole serum by immunoaffinity chromatography.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab81516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa).
IHC-Fr Use a concentration of 10 µg/ml.

靶标

  • 功能Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • 组织特异性Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • 序列相似性Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ig IL1 related receptor antibody
    • MGC110992 antibody
    • SIGIR_HUMAN antibody
    • SIGIRR antibody
    • Single Ig IL 1 related receptor antibody
    • Single Ig IL-1-related receptor antibody
    • Single Ig IL-1R-related molecule antibody
    • Single Ig IL1R Related Molecule antibody
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
    • Single immunoglobulin and toll interleukin 1 receptor domain antibody
    • Single immunoglobulin domain containing IL1R related protein antibody
    • Single immunoglobulin domain IL1R1 related antibody
    • Single immunoglobulin domain-containing IL1R-related protein antibody
    • TIR 8 antibody
    • TIR8 antibody
    • Toll/interleukin 1 receptor 8 antibody
    • Toll/interleukin-1 receptor 8 antibody
    see all

Anti-SIGIRR antibody (ab81516)参考文献

ab81516 has not yet been referenced specifically in any publications.

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