概述

  • 产品名称Anti-SIGIRR抗体
    参阅全部 SIGIRR 一抗
  • 描述
    兔多克隆抗体to SIGIRR
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region of human SIGIRR (XP_001129013)

  • 阳性对照
    • Jurkat cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab76401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:62500.

IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • 组织特异性Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • 序列相似性Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ig IL1 related receptor antibody
    • MGC110992 antibody
    • SIGIR_HUMAN antibody
    • SIGIRR antibody
    • Single Ig IL 1 related receptor antibody
    • Single Ig IL-1-related receptor antibody
    • Single Ig IL-1R-related molecule antibody
    • Single Ig IL1R Related Molecule antibody
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
    • Single immunoglobulin and toll interleukin 1 receptor domain antibody
    • Single immunoglobulin domain containing IL1R related protein antibody
    • Single immunoglobulin domain IL1R1 related antibody
    • Single immunoglobulin domain-containing IL1R-related protein antibody
    • TIR 8 antibody
    • TIR8 antibody
    • Toll/interleukin 1 receptor 8 antibody
    • Toll/interleukin-1 receptor 8 antibody
    see all

Anti-SIGIRR antibody 图像

  • Anti-SIGIRR antibody (ab76401) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 25 kDa
  • Immunohistochemistry of Liver tissue at an antibody concentration of 5 µg/ml using anti-SIGIRR antibody (ab76401)

Anti-SIGIRR antibody (ab76401)参考文献

ab76401 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab76401.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"