The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 µg/ml.
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 47 kDa.
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Belongs to the interleukin-1 receptor family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain.