概述

  • 产品名称
  • 描述
    兔多克隆抗体to SIAT4A
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-165 of Human SIAT4A (NM_003033).

  • 阳性对照
    • 293T, A431, H1299 Cell lysate. HeLaS3 whole cell lysate (WB). Sections of serous OVCA (IF).

性能

应用

Our Abpromise guarantee covers the use of ab96129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 39 kDa.
IHC-P 1/100.

靶标

  • 功能
    It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
  • 组织特异性
    Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.
  • 通路
    Protein modification; protein glycosylation.
  • 序列相似性
    Belongs to the glycosyltransferase 29 family.
  • 翻译后修饰
    The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位
    Golgi apparatus > Golgi stack membrane. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3-GalNAc-alpha-2 antibody
    • 3-sialyltransferase 1 antibody
    • 3-sialyltransferase antibody
    • 3-ST 1 antibody
    • Alpha 2 antibody
    • Alpha 23 ST antibody
    • Beta galactoside alpha 23 sialyltransferase antibody
    • Beta-galactoside alpha-2 antibody
    • beta-galactoside alpha-2,3-sialyltransferase 1 antibody
    • CMP N acetylneuraminate beta galactosamide alpha 23 sialyltransferase antibody
    • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2 antibody
    • DKFZp666E036 antibody
    • DKFZp779K2051 antibody
    • FLJ36548 antibody
    • Gal beta 13 GalNAc alpha 23 sialyltransferase antibody
    • Gal NAc6S antibody
    • Gal-beta-1 antibody
    • Gal-NAc6S antibody
    • MGC9183 antibody
    • OTTHUMP00000226912 antibody
    • OTTHUMP00000226913 antibody
    • SIA4A_HUMAN antibody
    • Sialyltransferase 4A antibody
    • SIAT4-A antibody
    • SIAT4A antibody
    • SIATFL antibody
    • ST3Gal I antibody
    • ST3GAL1 antibody
    • ST3GalA antibody
    • ST3GalA.1 antibody
    • ST3GalI antibody
    • ST3GalIA antibody
    • ST3O antibody
    see all

图片

  • Anti-SIAT4A antibody (ab96129) at 1/500 dilution + HeLa S3 whole cell lysate at 30 µg

    Predicted band size : 39 kDa
  • ab96129 at 1/100 dilution staining SIAT4A in paraffin-embedded serous OVCA by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

文献

This product has been referenced in:
  • Wen KC  et al. a2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Oncotarget 8:29013-29027 (2017). WB, IHC . Read more (PubMed: 28423672) »
  • Bai Q  et al. Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma. BMC Cancer 15:880 (2015). Read more (PubMed: 26552809) »

See all 2 Publications for this product

客户评价及客户问答

Thank you for your enquiry. I can confirm that the protein database links on the datasheet (SwissProt and Unigene) indicate that SIAT4A is expressed in pancreas. However, I am sorry I have done a literature search and I am not able to confirm t...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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