Anti-Siah2抗体- Aminoterminal end (ab59473)

概述

  • 产品名称Anti-Siah2抗体- Aminoterminal end
    参阅全部 Siah2 一抗
  • 描述
    兔多克隆抗体to Siah2 - Aminoterminal end
  • 经测试应用适用于: IHC-Fr, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: a wide range of other species
  • 免疫原

    Synthetic peptide derived from N terminal region of human Siah2

性能

应用

Our Abpromise guarantee covers the use of ab59473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/500 - 1/2000.
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/2000. Predicted molecular weight: 36 kDa.

靶标

  • 功能E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.
  • 组织特异性Widely expressed at low level.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the SINA (Seven in absentia) family.
    Contains 1 RING-type zinc finger.
    Contains 1 SIAH-type zinc finger.
  • 结构域The RING-type zinc finger domain is essential for ubiquitin ligase activity.
    The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
  • 细胞定位Cytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Partially nuclear.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 ubiquitin-protein ligase Siah2 antibody
    • hSiah2 antibody
    • Seven in absentia homolog 2 antibody
    • Siah E3 ubiquitin protein ligase 2 antibody
    • Siah-2 antibody
    • siah2 antibody
    • SIAH2_HUMAN antibody
    • Ubiquitin Ligase Siah2 antibody
    see all

Anti-Siah2 antibody - Aminoterminal end (ab59473)参考文献

ab59473 has not yet been referenced specifically in any publications.

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