The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
功能Plays an important role in the final stage of carbohydrate digestion.
组织特异性Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
疾病相关Defects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
序列相似性Belongs to the glycosyl hydrolase 31 family. Contains 2 P-type (trefoil) domains.
翻译后修饰The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen. Sulfated.
形式Sucrase-isomaltase is composed of 2 polypeptide chains of similar size linked together by noncovalent bonds. The polypeptide chains show a high degree of overlapping substrate specificity and are synthesized as 1 long polypeptide chain which, by means of pancreatic proteases, is later split into the 2 subunits.
Oligosaccharide alpha 1, 6 glucosidase antibody
sucrase isomaltase alpha glucosidase antibody
sucrase isomaltase antibody
Sucrase-isomaltase, intestinal antibody
Anti-SI antibody [4C5G6] (ab105467)参考文献
has not yet been referenced specifically in any publications.