Anti-SI抗体[4C5G6] (ab105467)

概述

  • 产品名称Anti-SI抗体[4C5G6]
    参阅全部 SI 一抗
  • 描述
    小鼠单克隆抗体[4C5G6] to SI
  • 经测试应用适用于: IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O

  • 常规说明Growth Conditions: RPMI 1640 + 20% FCS containing 10-6 M thymidine, 1.6x10-7 M hypoxanthine and 10-5 M methotrexate.


    ab105467 can be used for the detection of sucrase isomaltase in clinical material to test for loss of absorptive function/sucrose intolerance.

性能

应用

Our Abpromise guarantee covers the use of ab105467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution.

靶标

  • 功能Plays an important role in the final stage of carbohydrate digestion.
  • 组织特异性Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • 疾病相关Defects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
  • 序列相似性Belongs to the glycosyl hydrolase 31 family.
    Contains 2 P-type (trefoil) domains.
  • 翻译后修饰The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
    Sulfated.
  • 细胞定位Apical cell membrane. Brush border.
  • Information by UniProt
  • 数据库链接
  • 形式Sucrase-isomaltase is composed of 2 polypeptide chains of similar size linked together by noncovalent bonds. The polypeptide chains show a high degree of overlapping substrate specificity and are synthesized as 1 long polypeptide chain which, by means of pancreatic proteases, is later split into the 2 subunits.
  • 别名
    • Isomaltase antibody
    • MGC131621 antibody
    • MGC131622 antibody
    • Oligosaccharide alpha 1, 6 glucosidase antibody
    • SI antibody
    • sucrase isomaltase alpha glucosidase antibody
    • sucrase isomaltase antibody
    • Sucrase-isomaltase, intestinal antibody
    • SUIS_HUMAN antibody
    see all

Anti-SI antibody [4C5G6] (ab105467)参考文献

ab105467 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105467.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"