Anti-Shwachman Bodian-Diamond syndrome抗体(ab59642)


  • 产品名称
    Anti-Shwachman Bodian-Diamond syndrome抗体
    参阅全部 Shwachman Bodian-Diamond syndrome 一抗
  • 描述
    兔多克隆抗体to Shwachman Bodian-Diamond syndrome
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide: YGQQLEIVCL IDPGCFREID ELIKKETKGK GSLEVLNLKD VEEGDEKFE, corresponding to amino acids 202-250 of Human Shwachman Bodian-Diamond syndrome

  • 阳性对照
    • Jurkat cell lysate and Human kidney tissue.


  • 形式
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
  • 同种型
  • 研究领域


Our Abpromise guarantee covers the use of ab59642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 29 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.


  • 功能
    Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
  • 组织特异性
    Widely expressed.
  • 疾病相关
    Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS) [MIM:260400]. SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
  • 序列相似性
    Belongs to the SDO1/SBDS family.
  • 细胞定位
    Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4733401P19Rik antibody
    • AI836084 antibody
    • CGI 97 antibody
    • CGI-97 antibody
    • FLJ10917 antibody
    • MGC105922 antibody
    • Protein 22A3 antibody
    • Ribosome maturation protein SBDS antibody
    • sbds antibody
    • SBDS_HUMAN antibody
    • SDS antibody
    • Shwachman Bodian Diamond syndrome protein antibody
    • Shwachman Bodian Diamond syndrome protein homolog antibody
    • Shwachman-Bodian-Diamond syndrome protein antibody
    • SWDS antibody
    see all

Anti-Shwachman Bodian-Diamond syndrome antibody 图像

  • Anti-Shwachman Bodian-Diamond syndrome antibody (ab59642) at 1.25 µg/ml + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 29 kDa
    Observed band size : 29 kDa
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling Shwachman Bodian-Diamond syndrome with ab59642 at 4-8µg/ml. Arrows indicate positively labelled epithelial cells of the renal tubule. Magnification: 400X.

Anti-Shwachman Bodian-Diamond syndrome antibody (ab59642)参考文献

ab59642 has not yet been referenced specifically in any publications.

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