Anti-SHP1抗体[M160] (ab76202)


  • 产品名称Anti-SHP1抗体[M160]
    参阅全部 SHP1 一抗
  • 描述
    小鼠单克隆抗体[M160] to SHP1
  • 特异性ab76202 does not cross-react with SHP2.
  • 经测试应用适用于: WB, IP, ELISA, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein containing amino acids in the C terminal region of human SHP1.

  • 阳性对照
    • Jurkat cells treated with pervanadate (1 mM) for 30 min.



Our Abpromise guarantee covers the use of ab76202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
IP 1/100.
ELISA 1/2000.
ICC 1/100.


  • 功能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • 组织特异性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Phosphorylated on serine and tyrosine residues.
  • 细胞定位Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 70Z-SHP antibody
    • EC antibody
    • HCP antibody
    • HCPH antibody
    • Hematopoietic cell phosphatase antibody
    • Hematopoietic cell protein tyrosine phosphatase antibody
    • Hematopoietic cell protein-tyrosine phosphatase antibody
    • HPTP1C antibody
    • Protein tyrosine phosphatase 1C antibody
    • Protein tyrosine phosphatase non receptor type 6 antibody
    • Protein tyrosine phosphatase SHP1 antibody
    • Protein-tyrosine phosphatase 1C antibody
    • protein-tyrosine phosphatase SHP 1 antibody
    • Protein-tyrosine phosphatase SHP-1 antibody
    • PTN6_HUMAN antibody
    • PTP 1C antibody
    • PTP-1C antibody
    • PTP1C antibody
    • Ptpn6 antibody
    • SH PTP 1 antibody
    • SH PTP1 antibody
    • SH-PTP1 antibody
    • SHP 1 antibody
    • SHP 1L antibody
    • SHP1 antibody
    • SHP1L antibody
    • tyrosine protein phosphatase non receptor type 6 antibody
    • Tyrosine-protein phosphatase non-receptor type 6 antibody
    see all

Anti-SHP1 antibody [M160] 图像

  • All lanes : Anti-SHP1 antibody [M160] (ab76202) at 1/500 dilution

    Lane 1 : Jurkat cells treated with pervanadate (1 mM) for 30 min
    Lane 2 : Jurkat cells treated with pervanadate (1 mM) for 30 min and treated with lambda phosphatase

    Predicted band size : 68 kDa
    Observed band size : 68 kDa

Anti-SHP1 antibody [M160] (ab76202)参考文献

ab76202 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (Differentiated 3T3-L1 adipocytes)
Gel Running Conditions Reduced Denaturing (8.5%)
Loading amount 30 µg
Treatment Transfected with scramble or Shp1 shRNA
Specification Differentiated 3T3-L1 adipocytes
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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提交于 Aug 30 2016