Anti-Shoc2 / Sur8抗体(ab106430)

概述

  • 产品名称Anti-Shoc2 / Sur8抗体
    参阅全部 Shoc2 / Sur8 一抗
  • 描述
    兔多克隆抗体to Shoc2 / Sur8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 21 amino acid peptide near the N terminus of Human Shoc2/ Sur8 (NP_031399).

  • 阳性对照
    • Jurkat cell lysate; Human spleen tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.

靶标

  • 功能Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
  • 疾病相关Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
  • 序列相似性Belongs to the SHOC2 family.
    Contains 20 LRR (leucine-rich) repeats.
  • 细胞定位Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0862 antibody
    • Leucine-rich repeat protein SHOC-2 antibody
    • Protein soc-2 homolog antibody
    • Protein Sur-8 homolog antibody
    • Ras-binding protein Sur-8 antibody
    • SHOC2 antibody
    • SHOC2_HUMAN antibody
    see all

Anti-Shoc2 / Sur8 antibody 图像

  • Lane 1 : Anti-Shoc2 / Sur8 antibody (ab106430) at 1 µg/ml
    Lane 2 : Anti-Shoc2 / Sur8 antibody (ab106430) at 2 µg/ml

    Lane 1 : Jurkat cell lysate
    Lane 2 : Jurkat cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 65 kDa
  • ab106430, at 5 µg/ml, staining Shoc2 / Sur8 in paraffin embedded Human spleen tissue by Immunohistochemistry.

Anti-Shoc2 / Sur8 antibody (ab106430)参考文献

ab106430 has not yet been referenced specifically in any publications.

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