Recombinant protein fragment corresponding to a region within amino acids 162 and 447 of Human SHKBP1 (NP_612401).
A431 and H1299 cell lysates; PC13 xenograft
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
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Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 76 kDa.
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Belongs to the KCTD3 family.
Contains 1 BTB (POZ) domain. Contains 8 WD repeats.
Information by UniProt
SH3KBP1 binding protein 1 antibody
Western blot - SHKBP1 antibody (ab98148)
Anti-SHKBP1 antibody (ab98148) at 1/500 dilution + A431 whole cell lysate at 30 µg
Predicted band size: 76 kDa 7.5% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SHKBP1 antibody (ab98148)
Immunohistochemical analysis of SHKBP1 in paraffin embedded PC13 xenograft, using ab98148 at a 1/100 dilution.
has not yet been referenced specifically in any publications.
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