Anti-SHFM3抗体(ab60116)

概述

  • 产品名称Anti-SHFM3抗体
    参阅全部 SHFM3 一抗
  • 描述
    兔多克隆抗体to SHFM3
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    C-terminal synthetic peptide (Human) conjugated to KLH

  • 阳性对照
    • IHC-P: Human hepatocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab60116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
  • 组织特异性Expressed in brain, kidney, lung and liver.
  • 疾病相关Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) [MIM:246560]. SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.
  • 序列相似性Contains 1 F-box domain.
    Contains 4 WD repeats.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DAC antibody
    • Dactylin antibody
    • F box and WD 40 domain containing protein 4 antibody
    • F box and WD 40 domain protein 4 antibody
    • F box and WD repeat domain containing 4 antibody
    • F box/WD repeat containing protein 4 antibody
    • F box/WD repeat protein 4 antibody
    • F-box and WD-40 domain-containing protein 4 antibody
    • F-box/WD repeat-containing protein 4 antibody
    • FBW 4 antibody
    • FBW4 antibody
    • FBWD 4 antibody
    • FBWD4 antibody
    • FBXW 4 antibody
    • FBXW4 antibody
    • FBXW4_HUMAN antibody
    • OTTHUMP00000059175 antibody
    • SHFM 3 antibody
    • SHSF 3 antibody
    • SHSF3 antibody
    • Split hand/foot malformation (ectrodactyly) type antibody
    see all

Anti-SHFM3 antibody 图像

  • ab60116, at 1/100 dilution, staining SHFM3 in formalin-fixed, paraffin-embedded human hepatocarcinoma tissue by immunohistochemistry. ab60116 was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-SHFM3 antibody (ab60116)参考文献

ab60116 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (293FT)
Loading amount 20 µg
Specification 293FT
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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提交于 Aug 10 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"