产品名称 Anti-SHC4 (phospho)抗体 参阅全部 SHC4 一抗
兔多克隆抗体to SHC4 (phospho)
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Recombinant fragment containing a sequence corresponding to a region within amino acids 352-609 of Human SHC4 (NP_976224).
MOLT4 whole cell lysate; A431 lysate
存放说明 Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
存储溶液 Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
Concentration information loading...
纯度 Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 69 kDa.
功能 Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
组织特异性 Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
序列相似性 Contains 1 PID domain. Contains 1 SH2 domain.
翻译后修饰 Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
细胞定位 Cell junction > synapse > postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction.
Information by UniProt
Rai like protein antibody
Anti-SHC4 (phospho) antibody 图像
Anti-SHC4 (phospho) antibody (ab96182)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"