Anti-SHC4 (phospho)抗体(ab96182)

概述

  • 产品名称
    Anti-SHC4 (phospho)抗体
    参阅全部 SHC4 一抗
  • 描述
    兔多克隆抗体to SHC4 (phospho)
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment containing a sequence corresponding to a region within amino acids 352-609 of Human SHC4 (NP_976224).

  • 阳性对照
    • MOLT4 whole cell lysate; A431 lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab96182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.

靶标

  • 功能
    Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
  • 组织特异性
    Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
  • 序列相似性
    Contains 1 PID domain.
    Contains 1 SH2 domain.
  • 翻译后修饰
    Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
  • 细胞定位
    Cell junction > synapse > postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hShcD antibody
    • MGC34023 antibody
    • Rai like protein antibody
    • Rai-like protein antibody
    • RaLP antibody
    • SH2 domain protein C4 antibody
    • SHC (Src homology 2 domain containing) family member 4 antibody
    • SHC 4 antibody
    • SHC adaptor protein 4 antibody
    • SHC antibody
    • SHC family member 4 antibody
    • SHC transforming protein 4 antibody
    • SHC transforming protein D antibody
    • SHC-transforming protein 4 antibody
    • SHC-transforming protein D antibody
    • Shc4 antibody
    • SHC4_HUMAN antibody
    • SHCD antibody
    • Src homology 2 domain containing family member 4 antibody
    • Src homology 2 domain containing transforming protein C4 antibody
    • Src homology 2 domain-containing-transforming protein C4 antibody
    see all

图片

  • Anti-SHC4 (phospho) antibody (ab96182) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 69 kDa

实验方案

文献

ab96182 has not yet been referenced specifically in any publications.

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