概述

  • 产品名称Anti-SHB抗体
    参阅全部 SHB 一抗
  • 描述
    兔多克隆抗体to SHB
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50,

    MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSA

    , of Human SHB (NP_003019)

  • 阳性对照
    • HepG2 cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab98007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • 组织特异性Widely expressed.
  • 序列相似性Contains 1 SH2 domain.
  • 结构域The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • 翻译后修饰Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • 细胞定位Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bA3J10.2 antibody
    • OTTHUMP00000021397 antibody
    • RP11 3J10.8 antibody
    • RP113J10.8 antibody
    • SH2 domain containing adapter protein B antibody
    • SH2 domain-containing adapter protein B antibody
    • SHB (Src homology 2 domain containing) adaptor protein B antibody
    • SHB adaptor protein (a Src homology 2 protein) antibody
    • SHB adaptor protein antibody
    • Shb antibody
    • SHB_HUMAN antibody
    • Src homology 2 domain containing adaptor protein B antibody
    • Src homology 2 protein antibody
    see all

Anti-SHB antibody 图像

  • Anti-SHB antibody (ab98007) at 1 µg/ml (in 5% skim milk/ PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa

Anti-SHB antibody (ab98007)参考文献

ab98007 has not yet been referenced specifically in any publications.

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