概述

  • 产品名称Anti-SH3PXD2B抗体
    参阅全部 SH3PXD2B 一抗
  • 描述
    兔多克隆抗体to SH3PXD2B
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 300-350 of Human SH3PXD2B using the numbering given in entry NP_001017995.1.

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab123503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
    • 组织特异性Expressed in fibroblasts.
    • 疾病相关Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS) [MIM:249420]. It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers.
    • 序列相似性Belongs to the SH3PXD2 family.
      Contains 1 PX (phox homology) domain.
      Contains 4 SH3 domains.
    • 结构域The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-biphosphate (PtdIns(5)P), and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain.
    • 翻译后修饰Phosphorylated in SRC-transformed cells.
    • 细胞定位Cytoplasm. Cell projection > podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Adapter protein HOFI antibody
      • Factor for adipocyte differentiation 49 antibody
      • FAD49 antibody
      • FLJ20831 antibody
      • FTHS antibody
      • KIAA1295 antibody
      • SH3 and PX domain-containing protein 2B antibody
      • SH3PXD2B antibody
      • SPD2B_HUMAN antibody
      • TKS4 antibody
      • Tyrosine kinase substrate with four SH3 domains antibody
      see all

    Anti-SH3PXD2B antibody 图像

    • Detection of Human SH3PXD2B by Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab123503 at 6 µg/mg lysate for IP
      Subsequent Western blot detection used an antibody which recognized a downstream epitope of SH3PXD2B.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    Anti-SH3PXD2B antibody (ab123503)参考文献

    ab123503 has not yet been referenced specifically in any publications.

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