概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-HKGAIEKVKESDK
    • 氨基酸510 to 522

技术指标

Our Abpromise guarantee covers the use of ab45878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SH3PX1 antibody (ab45866)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • MST 155
    • MST155
    • MSTP 155
    • MSTP155
    • OTTHUMP00000040083
    • Protein SDP 1
    • Protein SDP1
    • SDP 1
    • SDP1
    • SH3 and PX domain containing protein 3A
    • SH3 and PX domain containing protein SH3PX1
    • SH3 and PX domain-containing protein 1
    • SH3 and PX domain-containing protein 3A
    • SH3PX1
    • SH3PXD3A
    • SNX 9
    • SNX9
    • SNX9_HUMAN
    • Sorting nexin 9
    • Sorting nexin-9
    • WASP interactor protein
    • Wiskott Aldrich syndrome protein (WASP) interactor protein
    • Wiskott Aldrich syndrome protein interactor protein
    • WISP
    see all
  • 功能May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
  • 序列相似性Belongs to the sorting nexin family.
    Contains 1 BAR domain.
    Contains 1 PX (phox homology) domain.
    Contains 1 SH3 domain.
  • 结构域The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol-4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
  • 翻译后修饰Ubiquitinated by ITCH.
    Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
  • 细胞定位Cytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
  • Information by UniProt

SH3PX1 peptide (510-522) (ab45878)参考文献

ab45878 has not yet been referenced specifically in any publications.

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