概述

  • 产品名称Anti-SH3KBP1抗体
    参阅全部 SH3KBP1 一抗
  • 描述
    兔多克隆抗体to SH3KBP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 144-193 (TGMFPSNFIK ELSGESDELG ISQDEQLSKS SLRETTGSES DGGDSSSTKS) of Human SH3KBP1 (NP_001019837)

  • 阳性对照
    • Jurkat cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab104295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
  • 组织特异性Ubiquitously expressed. Also expressed in some cancer cell lines.
  • 序列相似性Contains 3 SH3 domains.
  • 结构域The SH3 domains mediate interaction with SHKBP1.
  • 翻译后修饰Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
  • 细胞定位Cytoplasm > cytoskeleton. Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome. Cell junction > focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c Cbl interacting protein antibody
    • Cbl interacting protein antibody
    • Cbl interacting protein of 85 kDa antibody
    • Cbl-interacting protein of 85 kDa antibody
    • CD2 binding protein 3 antibody
    • CD2-binding protein 3 antibody
    • CD2BP3 antibody
    • CIN 85 antibody
    • CIN85 antibody
    • GIG 10 antibody
    • GIG10 antibody
    • HSB 1 antibody
    • HSB-1 antibody
    • HSB1 antibody
    • Human Src family kinase binding protein 1 antibody
    • Human Src family kinase-binding protein 1 antibody
    • MIG 18 antibody
    • MIG18 antibody
    • Migration inducing gene 18 antibody
    • Migration inducing gene 18 protein antibody
    • SH3 domain kinase binding protein 1 antibody
    • SH3 domain-containing kinase-binding protein 1 antibody
    • SH3BP 1 antibody
    • SH3K1_HUMAN antibody
    • SH3KBP1 antibody
    • Src family kinase binding protein 1 antibody
    • src related kinase binding protein 1 antibody
    see all

Anti-SH3KBP1 antibody 图像

  • Anti-SH3KBP1 antibody (ab104295) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 73 kDa

Anti-SH3KBP1 antibody (ab104295)参考文献

ab104295 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab104295.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"