Anti-SH3BP4抗体(ab57005)

概述

  • 产品名称Anti-SH3BP4抗体
    参阅全部 SH3BP4 一抗
  • 描述
    小鼠单克隆抗体to SH3BP4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-110 of Human SH3BP4

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.
    • 组织特异性Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
    • 序列相似性Contains 1 SH3 domain.
    • 结构域The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity.
    • 翻译后修饰Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
    • 细胞定位Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BOG25 antibody
      • EH binding protein antibody
      • EH binding protein 10 antibody
      • EH-binding protein 10 antibody
      • EHB10 antibody
      • SH3 domain binding protein 4 antibody
      • SH3 domain-binding protein 4 antibody
      • SH3B4_HUMAN antibody
      • sh3bp4 antibody
      • Transferrin receptor trafficking protein antibody
      • Transferrin receptor-trafficking protein antibody
      • TTP antibody
      see all

    Anti-SH3BP4 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57005 SH3BP4 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-SH3BP4 antibody (ab57005)参考文献

    ab57005 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for contacting Abcam regarding our SH3BP4 antibodies.


    Regarding ab106609, this antibody is specific for isoform 1.


    The immunogen of antibody ab57005 shares 97% identity with the mouse and rat sequences, thus it is ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"