Anti-SH3BP4抗体(ab106609)

概述

  • 产品名称Anti-SH3BP4抗体
    参阅全部 SH3BP4 一抗
  • 描述
    兔多克隆抗体to SH3BP4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to 18 amino acids near the C terminal end of Human SH3BP4 (NP_055336).

  • 阳性对照
    • Rat lung tissue lysate. Human lung tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (stable for up to 12 months).
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab106609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 107 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.
  • 组织特异性Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
  • 序列相似性Contains 1 SH3 domain.
  • 结构域The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity.
  • 翻译后修饰Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
  • 细胞定位Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BOG25 antibody
    • EH binding protein antibody
    • EH binding protein 10 antibody
    • EH-binding protein 10 antibody
    • EHB10 antibody
    • SH3 domain binding protein 4 antibody
    • SH3 domain-binding protein 4 antibody
    • SH3B4_HUMAN antibody
    • sh3bp4 antibody
    • Transferrin receptor trafficking protein antibody
    • Transferrin receptor-trafficking protein antibody
    • TTP antibody
    see all

Anti-SH3BP4 antibody 图像

  • Lane 1 : Anti-SH3BP4 antibody (ab106609) at 1 µg/ml
    Lane 2 : Anti-SH3BP4 antibody (ab106609) at 2 µg/ml

    Lane 1 : Rat lung tissue lysate
    Lane 2 : Rat lung tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 107 kDa
  • ab106609, at 5µg/ml, staining SH3BP4 in paraffin embedded Human lung tissue by Immunohistochemistry.

Anti-SH3BP4 antibody (ab106609)参考文献

ab106609 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding our SH3BP4 antibodies.


Regarding ab106609, this antibody is specific for isoform 1.


The immunogen of antibody ab57005 shares 97% identity with the mouse and rat sequences, thus it is ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"