Anti-SH3BP4抗体[2992C1a] (ab84853)

概述

  • 产品名称Anti-SH3BP4抗体[2992C1a]
    参阅全部 SH3BP4 一抗
  • 描述
    小鼠单克隆抗体[2992C1a] to SH3BP4
  • 经测试应用适用于: Dot blot, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment with a tag corresponding to N terminal amino acids 28-217 of Human SH3BP4.

  • 阳性对照
    • Immunising recombinant Human SH3BP4 protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab84853 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 µm membrane.
  • 克隆单克隆
  • 克隆编号2992C1a
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 107 kDa.

靶标

  • 功能Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.
  • 组织特异性Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
  • 序列相似性Contains 1 SH3 domain.
  • 结构域The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity.
  • 翻译后修饰Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
  • 细胞定位Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BOG25 antibody
    • EH binding protein antibody
    • EH binding protein 10 antibody
    • EH-binding protein 10 antibody
    • EHB10 antibody
    • SH3 domain binding protein 4 antibody
    • SH3 domain-binding protein 4 antibody
    • SH3B4_HUMAN antibody
    • sh3bp4 antibody
    • Transferrin receptor trafficking protein antibody
    • Transferrin receptor-trafficking protein antibody
    • TTP antibody
    see all

Anti-SH3BP4 antibody [2992C1a] 图像

Anti-SH3BP4 antibody [2992C1a] (ab84853)参考文献

ab84853 has not yet been referenced specifically in any publications.

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