概述

  • 产品名称Anti-SH3BP2抗体
    参阅全部 SH3BP2 一抗
  • 描述
    兔多克隆抗体to SH3BP2
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 150-200 of Human SH3BP2 (NP_001116153.1).

  • 阳性对照
    • HeLa whole cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH 7 to 8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab117767 was affinity purified using an epitope specific to SH3BP2 immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab117767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 62 kDa.
IP Use at 2-10 µg/mg of lysate.

靶标

  • 功能Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
  • 组织特异性Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
  • 疾病相关Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
  • 序列相似性Contains 1 PH domain.
    Contains 1 SH2 domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3BP-2 antibody
    • 3BP2 antibody
    • 3BP2_HUMAN antibody
    • Abl SH3 binding protein 2 antibody
    • Cherubism antibody
    • CRBM antibody
    • CRPM antibody
    • FLJ42079 antibody
    • FLJ54978 antibody
    • RES4-23 antibody
    • SH3 domain binding protein 2 antibody
    • SH3 domain-binding protein 2 antibody
    • Sh3bp2 antibody
    • TNFAIP3 interacting protein 2 antibody
    see all

Anti-SH3BP2 antibody 图像

  • All lanes : Anti-SH3BP2 antibody (ab117767) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg

    Developed using the ECL technique

    Predicted band size : 62 kDa


    Exposure time : 3 minutes
  • Detection of SH3BP2 by Western Blot of Immunprecipitate.
    ab117767 at 1µg/ml staining SH3BP2 in HeLa whole cell lysate immunoprecipitated using ab117767 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Detection: Chemiluminescence with exposure time of 10 seconds.

Anti-SH3BP2 antibody (ab117767)参考文献

ab117767 has not yet been referenced specifically in any publications.

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