The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).
功能Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
组织特异性Ubiquitously expressed. Aberrantly expressed in some cancers.
序列相似性Contains 1 SH2 domain.
细胞定位Cytoplasm. Located at podocyte foot processes.