概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-HKRYFRKIKN
    • 氨基酸73 to 82

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SH2D1A/SAP antibody (ab36141)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • DSHP
    • Duncan disease SH2 protein
    • Duncan disease SH2-protein
    • EBVS
    • IMD5
    • LYP
    • MTCP1
    • SAP
    • SAP/SH2D1A
    • SH2 domain containing 1A
    • SH2 domain protein 1A
    • SH2 domain-containing protein 1A
    • SH21A_HUMAN
    • SH2D1A
    • Signaling lymphocyte activation molecule associated protein
    • Signaling lymphocytic activation molecule-associated protein
    • SLAM associated protein
    • SLAM associated protein/SH2 domain protein 1A
    • SLAM-associated protein
    • T cell signal transduction molecule SAP
    • T-cell signal transduction molecule SAP
    • XLP
    • XLPD
    see all
  • 功能Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • 组织特异性Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
  • 疾病相关Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • 序列相似性Contains 1 SH2 domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt

SH2D1A/SAP peptide (73-82) (ab45754)参考文献

ab45754 has not yet been referenced specifically in any publications.

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