Anti-SH2D1A/SAP抗体(ab36141)

概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab36141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1:16,000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 14 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
    • 组织特异性Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
    • 疾病相关Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
    • 序列相似性Contains 1 SH2 domain.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DSHP antibody
      • Duncan disease SH2 protein antibody
      • Duncan disease SH2-protein antibody
      • EBVS antibody
      • IMD5 antibody
      • LYP antibody
      • MTCP1 antibody
      • SAP antibody
      • SAP/SH2D1A antibody
      • SH2 domain containing 1A antibody
      • SH2 domain protein 1A antibody
      • SH2 domain-containing protein 1A antibody
      • SH21A_HUMAN antibody
      • SH2D1A antibody
      • Signaling lymphocyte activation molecule associated protein antibody
      • Signaling lymphocytic activation molecule-associated protein antibody
      • SLAM associated protein antibody
      • SLAM associated protein/SH2 domain protein 1A antibody
      • SLAM-associated protein antibody
      • T cell signal transduction molecule SAP antibody
      • T-cell signal transduction molecule SAP antibody
      • XLP antibody
      • XLPD antibody
      see all

    Anti-SH2D1A/SAP antibody 图像

    Anti-SH2D1A/SAP antibody (ab36141)参考文献

    ab36141 has not yet been referenced specifically in any publications.

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