概述

  • 产品名称Anti-SGCE抗体
    参阅全部 SGCE 一抗
  • 描述
    兔多克隆抗体to SGCE
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (TVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDP I) of human SGCE (NP_001092871).

  • 阳性对照
    • 721_B cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab84660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 组织特异性Ubiquitous.
  • 疾病相关Defects in SGCE are a cause of dystonia type 11 (DYT11) [MIM:159900]; also known as myoclonic dystonia or alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • 序列相似性Belongs to the sarcoglycan alpha/epsilon family.
  • 细胞定位Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • dystonia 11, myoclonic antibody
    • DYT11 antibody
    • Epsilon sarcoglycan antibody
    • Epsilon SG antibody
    • Epsilon-sarcoglycan antibody
    • Epsilon-SG antibody
    • ESG antibody
    • sarcoglycan, epsilon antibody
    • sgcE antibody
    • SGCE_HUMAN antibody
    see all

Anti-SGCE antibody 图像

  • Immunohistochemistry with pFA fixed Human skeletal muscle tissue at an antibody concentration of 5.0ug/ml using anti-SGCE antibody (ab84660)
  • ab84660 at a 1/500 dilution staining SGCE in Mouse cerebellum tissue by Immunohistochemistry.

  • Anti-SGCE antibody (ab84660) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 50 kDa
    Observed band size : 50 kDa

Anti-SGCE antibody (ab84660)参考文献

ab84660 has not yet been referenced specifically in any publications.

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