概述

  • 产品名称Anti-SFRP4抗体
    参阅全部 SFRP4 一抗
  • 描述
    山羊多克隆抗体to SFRP4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Pig
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human SFRP4.

  • 阳性对照
    • Human Skeletal Muscle (Interstitial Cells) tissue; Human uterus lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
  • 组织特异性Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
  • 序列相似性Belongs to the secreted frizzled-related protein (sFRP) family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 NTR domain.
  • 结构域The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Secreted. Cytoplasmic in ovarian tumor cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Frizzled protein antibody
    • Frizzled protein human endometrium antibody
    • FRP 4 antibody
    • FRP4 antibody
    • FrpHE antibody
    • human endometrium antibody
    • Secreted frizzled-related protein 4 antibody
    • sFRP-4 antibody
    • Sfrp4 antibody
    • SFRP4_HUMAN antibody
    see all

Anti-SFRP4 antibody 图像

  • ab122905, at 3.75 µg/ml, staining SFRP4 in Formalin-fixed, Paraffin-embedded Human Skeletal Muscle (interstitial cells) tissue by Immunohistochemistry.
  • Anti-SFRP4 antibody (ab122905) at 0.3 µg/ml + Human uterus lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 40 kDa

Anti-SFRP4 antibody (ab122905)参考文献

This product has been referenced in:
  • Zhang Z  et al. Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci 20:981-9 (2013). Read more (PubMed: 23322712) »

See 1 Publication for this product

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