Anti-SFRP2抗体(ab92667)
Key features and details
- Rabbit polyclonal to SFRP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SFRP2抗体
参阅全部 SFRP2 一抗 -
描述
兔多克隆抗体to SFRP2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to an internal sequence of Human SFRP2.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab92667于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 33 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 33 kDa. |
靶标
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功能
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. -
组织特异性
Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. -
序列相似性
Belongs to the secreted frizzled-related protein (sFRP) family.
Contains 1 FZ (frizzled) domain.
Contains 1 NTR domain. -
结构域
The FZ domain is involved in binding with Wnt ligands. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 6423 Human
- Entrez Gene: 20319 Mouse
- Entrez Gene: 310552 Rat
- Omim: 604157 Human
- SwissProt: Q96HF1 Human
- SwissProt: P97299 Mouse
- Unigene: 481022 Human
- Unigene: 19155 Mouse
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别名
- AI851596 antibody
- Frizzled related protein 2 antibody
- FRP 2 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab92667 被引用在 4 文献中.
- Peng X et al. Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. J Mol Cell Biol 13:41-58 (2021). PubMed: 33582796
- Wang JC et al. Loss of Sfrp2 contributes to the neurological disorders related with morphine withdrawal via Wnt/ß-catenin signaling. Behav Brain Res 359:609-618 (2019). PubMed: 30291843
- Li P et al. SFRP2 modulates non-small cell lung cancer A549 cell apoptosis and metastasis by regulating mitochondrial fission via Wnt pathways. Mol Med Rep 20:1925-1932 (2019). PubMed: 31257495
- West JD et al. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am J Physiol Cell Physiol 307:C415-30 (2014). PubMed: 24871858