概述
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产品名称Anti-SF3A1抗体
参阅全部 SF3A1 一抗 -
描述兔多克隆抗体to SF3A1
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宿主Rabbit
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经测试应用适用于: IHC-Pmore details
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种属反应性与反应: Mouse, Human
预测可用于: Rabbit, Horse, Cow, Dog, Ferret, Rhesus monkey, Gorilla, Orangutan
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免疫原
Synthetic peptide corresponding to a region between amino acids 300 and 350 of Human SF3A1 (NP_005868.1).
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阳性对照
- Human Anaplastic Thyroid Carcinoma, Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Small Cell Lung Cancer, Stomach Adenocarcinoma and Testicular Seminoma. Mouse Renal Cell Carcinoma and Teratoma.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab84698 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
应用说明
IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
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组织特异性Ubiquitously expressed.
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序列相似性Contains 2 SURP motif repeats.
Contains 1 ubiquitin-like domain. -
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
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细胞定位Nucleus.
- Information by UniProt
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数据库链接
- Entrez Gene: 10291 Human
- Entrez Gene: 67465 Mouse
- Omim: 605595 Human
- SwissProt: Q15459 Human
- SwissProt: Q8K4Z5 Mouse
- Unigene: 406277 Human
- Unigene: 505597 Human
- Unigene: 156914 Mouse
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别名
- Pre mRNA processing 21 antibody
- Pre mRNA splicing factor SF3a antibody
- PRP21 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SF3A1 antibody (ab84698)ab84698, at 1/250 dilution, staining SF3A1 in formalin-fixed, paraffin-embedded human pancreatic islet cell tumor by Immunohistochemistry, using DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SF3A1 antibody (ab84698)ab84698, at 1/100 dilution, staining SF3A1 in formalin-fixed, paraffin-embedded mouse teratoma by Immunohistochemistry, using DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SF3A1 antibody (ab84698)ab84698, at 1/100 dilution, staining SF3A1 in formalin-fixed, paraffin-embedded human breast carcinoma by Immunohistochemistry using a Red fluorescent goat anti-rabbit IgG highly cross adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.
文献
ab84698 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"