Anti-SETMAR抗体(ab110909)

概述

  • 产品名称Anti-SETMAR抗体
    参阅全部 SETMAR 一抗
  • 描述
    兔多克隆抗体to SETMAR
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence of Human SETMAR.

  • 阳性对照
    • Human lung carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab110909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
  • 组织特异性Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
  • 序列相似性In the N-terminal section; belongs to the histone-lysine methyltransferase family.
    In the C-terminal section; belongs to the mariner transposase family.
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • 结构域The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.
  • 细胞定位Nucleus. Chromosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Histone lysine N methyltransferase antibody
    • Histone lysine N methyltransferase SETMAR antibody
    • Hsmar 1 antibody
    • Hsmar1 antibody
    • Mariner transposase Hsmar1 antibody
    • Metnase antibody
    • SET domain and mariner transposase fusion antibody
    • SET domain and mariner transposase fusion gene antibody
    • SET domain and mariner transposase fusion gene containing protein antibody
    • SET domain and mariner transposase fusion gene-containing protein antibody
    • Setmar antibody
    • SETMR_HUMAN antibody
    see all

Anti-SETMAR antibody 图像

  • ab110909 at 1/50 dilution staining SETMAR in paraffin-embedded Human lung carcinoma tissue by Immunohistochemistry. The picture on the right is treated with the synthesized peptide.

Anti-SETMAR antibody (ab110909)参考文献

ab110909 has not yet been referenced specifically in any publications.

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