Anti-Serum Amyloid P抗体(ab17872)

概述

  • 产品名称Anti-Serum Amyloid P抗体
    参阅全部 Serum Amyloid P 一抗
  • 描述
    兔多克隆抗体to Serum Amyloid P
  • 特异性Specific for human SAP with no crossreactivity with CRP or other pentraxins.
  • 经测试应用适用于: WB, ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Full length native protein (purified) (Human).

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab17872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250 - 1/2500. Predicted molecular weight: 26.76 kDa.
ELISA 1/2500 - 1/10000.
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [14B4] to Serum Amyloid P (ab27313). Use as detection antibody with recommended pair. See Abreview submitted by Jennifer Webster for details.

靶标

  • 功能Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
  • 组织特异性Found in serum and urine.
  • 疾病相关Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
  • 序列相似性Belongs to the pentaxin family.
    Contains 1 pentaxin domain.
  • 翻译后修饰N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9.5S alpha 1 glycoprotein antibody
    • 9.5S alpha-1-glycoprotein antibody
    • Amyloid P component serum antibody
    • APCS antibody
    • MGC88159 antibody
    • Pentaxin related antibody
    • Pentraxin 2 antibody
    • PTX 2 antibody
    • PTX2 antibody
    • SAMP_HUMAN antibody
    • SAP antibody
    • Serum amyloid P component antibody
    • Serum amyloid P-component(1-203) antibody
    see all

Anti-Serum Amyloid P antibody (ab17872)参考文献

ab17872 has not yet been referenced specifically in any publications.

Product Wall

The reason why the customer is not seeing any bands is that normal brain has very very little SAP protein, therefore it is not surprising that the customer still sees no band. The reference below should be very useful, in particular, figure 3, whic...

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As Serum Amyloid P protein is only expressed in high levels in AD patients as is in low levels in normal subjects I think the problem is therefore low levels in the samples. Furthermore, the customer should try incubating in more concentrated antibo...

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Thank you for contacting us for technical support on behalf of your customer. Many thanks for providing so much protocol information and the images of the blot. It enabled me to understand the problem very easily and rapidly. I am a little confused...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application ELISA
Sample Human Serum (Serum)
Specification Serum
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5%
Type Sandwich
Username

Miss. Jennifer Webster

Verified customer

提交于 Aug 16 2006

Good morning, Unfortunately the source of ab17872 does not have an image of the western blot to provide us. I am very sorry for this inconvenience, Best of luck with your research,

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"