概述

  • 产品名称Anti-SerpinB6抗体
    参阅全部 SerpinB6 一抗
  • 描述
    兔多克隆抗体to SerpinB6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment containing a sequence corresponding to a region within amino acids 66-283 of Human SerpinB6 (AAH01394).

  • 阳性对照
    • A549 and HeLa whole cell lysates; HepG2 and HCT116 cell lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab97330 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 42 kDa.

靶标

  • 功能May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
  • 组织特异性Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
  • 疾病相关Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
  • 序列相似性Belongs to the serpin family. Ov-serpin subfamily.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAP antibody
    • Cytoplasmic antiproteinase antibody
    • Peptidase inhibitor 6 antibody
    • PI-6 antibody
    • PI6 antibody
    • Placental thrombin inhibitor antibody
    • Protease inhibitor 6 (placental thrombin inhibitor) antibody
    • PTI antibody
    • Serpin B6 antibody
    • SERPINB6 antibody
    • SPB6_HUMAN antibody
    see all

Anti-SerpinB6 antibody 图像

  • All lanes : Anti-SerpinB6 antibody (ab97330) at 1/1000 dilution

    Lane 1 : A549 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 42 kDa

Anti-SerpinB6 antibody (ab97330)参考文献

ab97330 has not yet been referenced specifically in any publications.

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