概述

  • 产品名称Anti-SerpinB6抗体
    参阅全部 SerpinB6 一抗
  • 描述
    山羊多克隆抗体to SerpinB6
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cynomolgus Monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    NWDEQFDKENTEER

    (Human) from the internal region of the protein sequence according to NP_004559.4.

  • 阳性对照
    • Human ovary lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/128000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
    • 组织特异性Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
    • 疾病相关Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
    • 序列相似性Belongs to the serpin family. Ov-serpin subfamily.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAP antibody
      • Cytoplasmic antiproteinase antibody
      • Peptidase inhibitor 6 antibody
      • PI-6 antibody
      • PI6 antibody
      • Placental thrombin inhibitor antibody
      • Protease inhibitor 6 (placental thrombin inhibitor) antibody
      • PTI antibody
      • Serpin B6 antibody
      • SERPINB6 antibody
      • SPB6_HUMAN antibody
      see all

    Anti-SerpinB6 antibody 图像

    • Anti-SerpinB6 antibody (ab77372) at 0.1 µg/ml + human ovary lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 42 kDa
      Observed band size : 42 kDa

    Anti-SerpinB6 antibody (ab77372)参考文献

    ab77372 has not yet been referenced specifically in any publications.

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