Anti-SerpinB6抗体[2F8] (ab119393)

概述

  • 产品名称Anti-SerpinB6抗体[2F8]
    参阅全部 SerpinB6 一抗
  • 描述
    小鼠单克隆抗体[2F8] to SerpinB6
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein of Human SerpinB6 produced in HEK293T cells (NP_004559).

  • 阳性对照
    • HEK293T cells transfected with SerpinB6, Carcinoma of Human kidney, Adenocarcinoma of Human endometrium and Carcinoma of Human bladder tissues
  • 常规说明Dilute in PBS (pH7.3) before use.

性能

应用

Our Abpromise guarantee covers the use of ab119393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 43 kDa.
IHC-P 1/150.

靶标

  • 功能May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
  • 组织特异性Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
  • 疾病相关Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
  • 序列相似性Belongs to the serpin family. Ov-serpin subfamily.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAP antibody
    • Cytoplasmic antiproteinase antibody
    • Peptidase inhibitor 6 antibody
    • PI-6 antibody
    • PI6 antibody
    • Placental thrombin inhibitor antibody
    • Protease inhibitor 6 (placental thrombin inhibitor) antibody
    • PTI antibody
    • Serpin B6 antibody
    • SERPINB6 antibody
    • SPB6_HUMAN antibody
    see all

Anti-SerpinB6 antibody [2F8] 图像

  • All lanes : Anti-SerpinB6 antibody [2F8] (ab119393) at 1/500 dilution

    Lane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control
    Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB6

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 43 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC203822)
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using ab119393 at a dilution of 1/150.

Anti-SerpinB6 antibody [2F8] (ab119393)参考文献

ab119393 has not yet been referenced specifically in any publications.

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