Serotonin N-acetyltransferase肽(ab4976)

概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab4976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Phospho-Ser206 AA-NAT, catalog ab3440. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • AA-NAT
    • Aanat
    • Aralkylamine N-acetyltransferase
    • Arylalkylamine N acetyltransferase
    • Serotonin acetylase
    • Serotonin N-acetyltransferase
    • SNAT
    • SNAT_HUMAN
    see all
  • 功能Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • 组织特异性Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
  • 通路Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
  • 疾病相关Delayed sleep phase syndrome
  • 序列相似性Belongs to the acetyltransferase family. AANAT subfamily.
    Contains 1 N-acetyltransferase domain.
  • 翻译后修饰cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Serotonin N-acetyltransferase peptide (ab4976)参考文献

ab4976 has not yet been referenced specifically in any publications.

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