Anti-Serotonin N-acetyltransferase抗体(ab3506)

概述

• 产品名称
  Anti-Serotonin N-acetyltransferase抗体
  参阅全部 Serotonin N-acetyltransferase 一抗
• 描述
  兔多克隆抗体to Serotonin N-acetyltransferase
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Rat
  预测可用于: Mouse, Hamster, Human, Chimpanzee, Rhesus monkey
• 免疫原

  Synthetic peptide corresponding to Rat Serotonin N-acetyltransferase aa 195-205 (C terminal).
  Sequence:

  CHTFLRRNSGC

  
  (Peptide available as ab5004)

  Run BLAST with Run BLAST with

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.05% Sodium azide
  Constituents: 0.1% BSA, 99% PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 纯化说明
  Total anti-C-terminal AA-NAT-specific IgG was affinity purified on resin-coupled non-phosphopeptide. Phospho-specific carboxy-terminal IgG was subsequently isolated on resin-coupled phosphopeptide.
• Primary antibody说明
  Pineal gland serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light/dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr29 and Ser206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation.
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Neuroscience
  • Neurotransmitter
  • Biogenic Amines
  • Serotonin / 5HT

  • Neuroscience
  • Neurology process
  • Circadian Rhythm
  • Hormones

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • Serotonin N-acetyltransferase peptide (ab5004)

应用

靶标

• 功能
  Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
• 组织特异性
  Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
• 通路
  Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
• 疾病相关
  Delayed sleep phase syndrome
• 序列相似性
  Belongs to the acetyltransferase family. AANAT subfamily.
  Contains 1 N-acetyltransferase domain.
• 翻译后修饰
  cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
• 细胞定位
  Cytoplasm.

• Target information above from: UniProt accession Q16613 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 503504 Chimpanzee
  • Entrez Gene: 15 Human
  • Entrez Gene: 11298 Mouse
  • Entrez Gene: 25120 Rat
  • Omim: 600950 Human
  • SwissProt: Q5IS55 Chimpanzee
  • SwissProt: Q16613 Human
  • SwissProt: O88816 Mouse

  • SwissProt: Q64666 Rat
  • Unigene: 431417 Human
  • Unigene: 418559 Mouse
  • Unigene: 42233 Mouse
  • Unigene: 88180 Rat

  see all
• 别名
  • AA-NAT antibody
  • Aanat antibody
  • Aralkylamine N-acetyltransferase antibody

  • Arylalkylamine N acetyltransferase antibody
  • Serotonin acetylase antibody
  • Serotonin N-acetyltransferase antibody
  • SNAT antibody
  • SNAT_HUMAN antibody

  see all

实验方案

• Western blot protocols