Anti-Serine/threonine-protein kinase 4抗体(ab25136)


  • 产品名称Anti-Serine/threonine-protein kinase 4抗体
    参阅全部 Serine/threonine-protein kinase 4 一抗
  • 描述
    兔多克隆抗体to Serine/threonine-protein kinase 4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Serine/threonine-protein kinase 4 (N terminal).
    (Peptide available as ab51929)



Our Abpromise guarantee covers the use of ab25136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1 - 4 µg/ml. Predicted molecular weight: 56 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
    • 组织特异性Ubiquitously expressed.
    • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SARAH domain.
    • 翻译后修饰Autophosphorylated on serine and threonine residues.
    • 细胞定位Cytoplasm. Nucleus. The caspase-cleaved form cycles between the nucleus and cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Kinase responsive to stress antibody
      • Krs2 antibody
      • Mammalian STE20 like protein kinase 1 antibody
      • Mammalian STE20-like protein kinase 1 antibody
      • Mammalian sterile 20 like 1 antibody
      • MST-1 antibody
      • MST1 antibody
      • Serine/threonine kinase 4 antibody
      • Serine/threonine protein kinase Krs 2 antibody
      • Serine/threonine-protein kinase 4 antibody
      • Serine/threonine-protein kinase Krs-2 antibody
      • STE20 like kinase MST1 antibody
      • STE20-like kinase MST1 antibody
      • STK4 antibody
      • STK4_HUMAN antibody
      • TIIAC antibody
      • YSK3 antibody
      see all

    Anti-Serine/threonine-protein kinase 4 antibody (ab25136)参考文献

    ab25136 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab25136.
    Please use the links above to contact us or submit feedback about this product.