Anti-Serine/threonine-protein kinase 4抗体(ab13865)

概述

  • 产品名称Anti-Serine/threonine-protein kinase 4抗体
    参阅全部 Serine/threonine-protein kinase 4 一抗
  • 描述
    兔多克隆抗体to Serine/threonine-protein kinase 4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Serine/threonine-protein kinase 4. Synthetic peptide corresponding to amino acids 372-390 (AEDEEEEGTMKRRDETMQP) of human MST-1.

  • 阳性对照
    • Jurkat whole cell lysate.
  • 常规说明Stable for 6 months at 4 °C.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab13865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 54 kDa.

靶标

  • 功能Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SARAH domain.
  • 翻译后修饰Autophosphorylated on serine and threonine residues.
  • 细胞定位Cytoplasm. Nucleus. The caspase-cleaved form cycles between the nucleus and cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Kinase responsive to stress antibody
    • Krs2 antibody
    • Mammalian STE20 like protein kinase 1 antibody
    • Mammalian STE20-like protein kinase 1 antibody
    • Mammalian sterile 20 like 1 antibody
    • MST-1 antibody
    • MST1 antibody
    • Serine/threonine kinase 4 antibody
    • Serine/threonine protein kinase Krs 2 antibody
    • Serine/threonine-protein kinase 4 antibody
    • Serine/threonine-protein kinase Krs-2 antibody
    • STE20 like kinase MST1 antibody
    • STE20-like kinase MST1 antibody
    • STK4 antibody
    • STK4_HUMAN antibody
    • TIIAC antibody
    • YSK3 antibody
    see all

Anti-Serine/threonine-protein kinase 4 antibody 图像



  • Predicted band size : 54 kDa
    Western blot analysis of MST1 in 15 ugs of Jurkat cell lysate using ab13865 at 1 ug/ml.

     

    Western blot analysis of MST1 in 15 ugs of Jurkat cell lysate using ab13865 at 1 ug/ml.

Anti-Serine/threonine-protein kinase 4 antibody (ab13865)参考文献

ab13865 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I was able to obtain the immunogen sequence from our source of ab13865. The immunogen is a synthetic peptide corresponding to amino acids 372-390 (AEDEEEEGTMKRRDETMQP) of human MST-1. Synonyms for MST-1 are the following...

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