概述

  • 产品名称Anti-Serglycin抗体
    参阅全部 Serglycin 一抗
  • 描述
    兔多克隆抗体to Serglycin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 5-54 (LLKCSRLVLA LALILVLESS VQGYPTRRAR YQWVRCNPDS NSANCLEEKG) of Human SRGN (NP_002718).

  • 阳性对照
    • Jurkat cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab123051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 序列相似性Belongs to the serglycin family.
  • 翻译后修饰O-glcosylated; contains chondroitin sulfate and heparan sulfate.
  • 细胞定位Cytoplasmic granule. Secreted > extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chondroitin sulfate proteoglycan core protein antibody
    • Cytolytic granule proteoglycan core protein antibody
    • FLJ12930 antibody
    • gp600 antibody
    • Hematopoetic proteoglycan core protein antibody
    • Mastocytoma proteoglycan core protein antibody
    • MGC9289 antibody
    • OTTHUMP00000019716 antibody
    • P.PG antibody
    • PG19 core protein antibody
    • Pgsg antibody
    • Platelet proteoglycan core protein antibody
    • platelet proteoglycan protein core antibody
    • PLATELET PROTEOGLYCAN PROTEIN CORE; PPG antibody
    • PPG antibody
    • PRG antibody
    • PRG1 antibody
    • PROTEOGLYCAN 1 antibody
    • proteoglycan 1, secretory granule antibody
    • Proteoglycan 10K core protein antibody
    • Proteoglycan peptide core protein antibody
    • PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE antibody
    • secretory granule proteoglycan 1 antibody
    • Secretory granule proteoglycan core peptide antibody
    • Secretory granule proteoglycan core protein antibody
    • Serglycin antibody
    • serglycin proteoglycan antibody
    • Sgc antibody
    • Srgn antibody
    • SRGN_HUMAN antibody
    see all

Anti-Serglycin antibody 图像

  • Anti-Serglycin antibody (ab123051) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 18 kDa

Anti-Serglycin antibody (ab123051)参考文献

ab123051 has not yet been referenced specifically in any publications.

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