Anti-SERCA1 ATPase抗体[1B11] (ab109899)

概述

  • 产品名称Anti-SERCA1 ATPase抗体[1B11]
    参阅全部 SERCA1 ATPase 一抗
  • 描述
    小鼠单克隆抗体[1B11] to SERCA1 ATPase
  • 经测试应用适用于: WB, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Cynomolgus Monkey
  • 免疫原

    Recombinant fragment: IDRCNYVRVG TTRVPLTGPV KEKIMAVIKE WGTGRDTLRC LALATRDTPP KREEMVLDDS ARFLEYETDL TFVGVVGMLD PPRKEVTGSI QL, corresponding to amino acids 522-613 of Human SERCA1 ATPase (NP_775293) with a proprietary tag.

  • 阳性对照
    • Human Heart and skeletal muscle tissue. Transfected 293T cell line. A431 cells.

性能

应用

Our Abpromise guarantee covers the use of ab109899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 110 kDa.
ELISA Use a concentration of 2.5 µg/ml.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
  • 组织特异性Skeletal muscle, fast twitch muscle (type II) fibers.
  • 疾病相关Brody myopathy
  • 序列相似性Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
  • 发展阶段Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult skeletal muscle, while isoform SERCA1B predominates in neo-natal skeletal muscle.
  • 细胞定位Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • fast twitch skeletal muscle isoform antibody
    • AT2A1_HUMAN antibody
    • ATP2A antibody
    • ATP2A1 antibody
    • ATPase Ca++ transporting cardiac muscle fast twitch 1 antibody
    • ATPase Ca++ transporting fast twitch 1 antibody
    • ATPase, Ca(2+)-transporting fast twitch 1 antibody
    • Calcium pump 1 antibody
    • Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform antibody
    • Calcium-transporting ATPase sarcoplasmic reticulum type antibody
    • EC 3.6.3.8 antibody
    • Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody
    • Fast skeletal muscle SR calcium ATPase antibody
    • OTTHUMP00000162561 antibody
    • OTTHUMP00000162562 antibody
    • Sarcoendoplasmic reticulum calcium ATPase antibody
    • Sarcoplasmic reticulum Ca(2+)-ATPase 1 antibody
    • Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 antibody
    • SERCA 1 antibody
    • SERCA1 antibody
    • SERCA1 truncated isoform, included antibody
    • SR Ca(2+) ATPase 1 antibody
    • SR Ca(2+)-ATPase 1 antibody
    see all

Anti-SERCA1 ATPase antibody [1B11] 图像

  • All lanes : Anti-SERCA1 ATPase antibody [1B11] (ab109899)

    Lane 1 : Transfected 293T cell line
    Lane 2 : Non-transfected 293T cell line


    Predicted band size : 110 kDa
  • Anti-SERCA1 ATPase antibody [1B11] (ab109899) + A431 cell lysate

    Predicted band size : 110 kDa
  • ab109899 at 5 µg/ml staining SERCA1 ATPase in Formalin-Fixed, Paraffin-Embedded Human heart by Immunohistochemistry.
  • ab109899 at 5 µg/ml staining SERCA1 ATPase in Formalin-Fixed, Paraffin-Embedded Human skeletal muscle by Immunohistochemistry.
  • ab109899 at 10 µg/ml staining SERCA1 ATPase in A431 cells by Immunofluorescence.

Anti-SERCA1 ATPase antibody [1B11] (ab109899)参考文献

ab109899 has not yet been referenced specifically in any publications.

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