Anti-Separase抗体[2329C1a] (ab84868)

概述

  • 产品名称Anti-Separase抗体[2329C1a]
    参阅全部 Separase 一抗
  • 描述
    小鼠单克隆抗体[2329C1a] to Separase
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Tagged recombinant fragment: NPGLNGRSRR AKKVASRHCE ERRPQRASDQ ARPGPEIMRT IPEEELTDNW RKMSFEILRG SDGEDSASGG KTPAPGPEAA SGEWELLRLD SSKKKLPSPC PDKESDKD, corresponding to internal sequence amino acids 1448-1555 of Human Separase

  • 阳性对照
    • Immunising recombinant Human Separase protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab84868 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 µm membrane.
  • 克隆单克隆
  • 克隆编号2329C1a
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 233 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
  • 序列相似性Belongs to the peptidase C50 family.
  • 翻译后修饰Autocleaves. This function, which is not essential for its protease activity, is unknown.
    Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Caspase like protein ESPL1 antibody
    • Caspase-like protein ESPL1 antibody
    • ESP 1 antibody
    • ESP1 antibody
    • ESPL 1 antibody
    • Espl1 antibody
    • ESPL1_HUMAN antibody
    • Extra spindle poles like 1 antibody
    • Extra spindle poles like 1 protein antibody
    • Extra spindle poles-like 1 protein antibody
    • FLJ46492 antibody
    • KIAA0165 antibody
    • Separase antibody
    • Separin antibody
    • Similar to fission yeast cut1and gene antibody
    • SSE antibody
    see all

Anti-Separase antibody [2329C1a] 图像

Anti-Separase antibody [2329C1a] (ab84868)参考文献

ab84868 has not yet been referenced specifically in any publications.

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