Anti-SENP6抗体- Carboxyterminal end (ab59899)

概述

  • 产品名称Anti-SENP6抗体- Carboxyterminal end
    参阅全部 SENP6 一抗
  • 描述
    兔多克隆抗体to SENP6 - Carboxyterminal end
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide selected from the C-terminal region of human SENP6 conjugated to KLH.

  • 阳性对照
    • HL60 cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab59899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Detects a band of approximately 126 kDa (predicted molecular weight: 126 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • 组织特异性Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • 通路Protein modification; protein sumoylation.
  • 序列相似性Belongs to the peptidase C48 family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2810017C20Rik antibody
    • FLJ11355 antibody
    • FLJ11887 antibody
    • KIAA0389 antibody
    • KIAA0797 antibody
    • SENP 6 antibody
    • Senp6 antibody
    • SENP6_HUMAN antibody
    • Sentrin specific protease 6 antibody
    • Sentrin-specific protease 6 antibody
    • Sentrin/SUMO specific protease SENP6 antibody
    • Sentrin/SUMO-specific protease SENP6 antibody
    • SSP 1 antibody
    • SSP1 antibody
    • SUMO 1 specific protease 1 antibody
    • SUMO 1 specific protease antibody
    • SUMO-1-specific protease 1 antibody
    • SUMO1 specific protease 1 antibody
    • SUMO1 specific protease antibody
    • SUMO1/sentrin specific peptidase 6 antibody
    • SUSP 1 antibody
    • SUSP1 antibody
    see all

Anti-SENP6 antibody - Carboxyterminal end 图像

  • Anti-SENP6 antibody - Carboxyterminal end (ab59899) at 1/100 dilution + HL60 cell lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 126 kDa
    Observed band size : 126 kDa
  • ab59899 at 1/100 dilution staining SENP6 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used followed by AEC staining.

Anti-SENP6 antibody - Carboxyterminal end (ab59899)参考文献

ab59899 has not yet been referenced specifically in any publications.

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