RabMAb

Anti-SENP3抗体[EP4360] (ab124790)

概述

  • 产品名称Anti-SENP3抗体[EP4360]
    参阅全部 SENP3 一抗
  • 描述
    兔单克隆抗体[EP4360] to SENP3
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C terminus of Human SENP3.

  • 阳性对照
    • MCF-7, Jurkat and HeLa cell lysates.
  • 常规说明

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EP4360
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 65 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
    • 序列相似性Belongs to the peptidase C48 family.
    • 细胞定位Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
    • Information by UniProt
    • 数据库链接
    • 别名
      • SENP3 antibody
      • SENP3_HUMAN antibody
      • Sentrin / SUMO specific protease 3 antibody
      • Sentrin specific protease 3 antibody
      • Sentrin-specific protease 3 antibody
      • Sentrin/SUMO-specific protease SENP3 antibody
      • SMT3IP1 antibody
      • SSP3 antibody
      • SUMO 1 specific protease 3 antibody
      • SUMO-1-specific protease 3 antibody
      • SUMO1 specific protease 3 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
      • SUSP3 antibody
      see all

    Anti-SENP3 antibody [EP4360] 图像

    • All lanes : Anti-SENP3 antibody [EP4360] (ab124790) at 1/1000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 65 kDa

    Anti-SENP3 antibody [EP4360] (ab124790)参考文献

    ab124790 has not yet been referenced specifically in any publications.

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