RabMAb

Anti-SENP3抗体[EP4360] (ab124790)

概述

  • 产品名称
    Anti-SENP3抗体[EP4360]
    参阅全部 SENP3 一抗
  • 描述
    兔单克隆抗体[EP4360] to SENP3
  • 经测试应用
    适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C terminus of Human SENP3.

  • 阳性对照
    • MCF-7, Jurkat and HeLa cell lysates.
  • 常规说明

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液
    PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 纯度
    Tissue culture supernatant
  • 克隆
    单克隆
  • 克隆编号
    EP4360
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 65 kDa.
  • 应用说明
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能
      Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
    • 序列相似性
      Belongs to the peptidase C48 family.
    • 细胞定位
      Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
    • Information by UniProt
    • 数据库链接
    • 别名
      • SENP3 antibody
      • SENP3_HUMAN antibody
      • Sentrin / SUMO specific protease 3 antibody
      • Sentrin specific protease 3 antibody
      • Sentrin-specific protease 3 antibody
      • Sentrin/SUMO-specific protease SENP3 antibody
      • SMT3IP1 antibody
      • SSP3 antibody
      • SUMO 1 specific protease 3 antibody
      • SUMO-1-specific protease 3 antibody
      • SUMO1 specific protease 3 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
      • SUSP3 antibody
      see all

    图片

    • All lanes : Anti-SENP3 antibody [EP4360] (ab124790) at 1/1000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 65 kDa

    实验方案

    文献

    ab124790 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab124790.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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